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Electronic communication

Shire will communicate with those shareholders who have elected or who are deemed to have elected to receive documents electronically by publishing documents on its website and will write to shareholders to inform them of the availability of these documents on the Company's website.

Alternatively, shareholders can elect to receive electronic notification of Company communications. Instead of a letter, an email will be sent to the shareholder's email address with a link to the documents on the Company's website. To effect this, you must register free of charge at www.shareview.co.uk by following the online instructions.

The advantages of electronic communication are:

  • Receiving shareholder information speedily and efficiently
  • Reducing the demand on natural resources
  • Helping your Company reduce its costs

Shareholders who do not elect to receive documents or notifications electronically will receive paper copies of materials.

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Shareholder security

Many companies have become aware that their shareholders have received unsolicited phone calls or correspondence concerning investment matters. These are typically from overseas-based 'brokers' who target UK shareholders, offering to sell them what often turn out to be worthless or high risk shares in US or UK investments.

Shareholders are advised to be very wary of any unsolicited advice, offers to buy shares at a discount or offers of free company reports. If you receive any unsolicited investment advice:

If you deal with an unauthorized firm, you will not be eligible to receive payment under the Financial Services Compensation Scheme.

Details of any share dealing facilities that the Company endorses will be included in Company mailings.

More detailed information on this or similar activity can be found on the FSA website www.moneymadeclear.fsa.gov.uk

This warning has been issued by the Financial Services Authority and endorsed by the Institute of Chartered Secretaries and Administrators.

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Financial calendar

Second interim dividend payment April 2010
Annual General Meeting April 2010
First quarter results announcement April 2010
Second quarter results announcement August 2010
First interim dividend payment September/October 2010
Third quarter results announcement October 2010
Annual results announcement February 2011
Second interim dividend payment April 2011

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Dividends

Shareholders are able to choose how they receive their dividends:

  • directly into their bank account* or
  • by cheque

*Shire preferred option:

The quickest and most efficient way to receive your dividends is to have them paid directly into your bank account. Those selecting this payment method receive a tax voucher with each payment. To change how you receive your dividends, either log on to www.shareview.co.uk or contact Equiniti.

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Income Access Share ('IAS') Arrangements

Shareholders who elect, or are deemed to have elected, to receive their dividends via the IAS arrangements will receive their dividends from a UK source (rather than directly from the Company which is an Irish tax resident company) for UK tax purposes.

Shareholders who hold 25,000 or fewer shares (i) on the date of admission of the Company to the London Stock Exchange, being May 23, 2008, and (ii) in the case of shareholders who did not own shares at that time, on the first dividend record date after they became shareholders in the Company, unless they elect otherwise, will be deemed to have elected to receive their dividends under the IAS arrangements.

Shareholders who hold more than 25,000 shares and who wish to receive their dividends from a UK source must make an IAS election. All elections remain in force indefinitely unless revoked.

Unless shareholders have made an IAS election, or are deemed to have made an IAS election, dividends will be received from an Irish source and will be taxed accordingly.

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ShareGift

Shareholders with a small number of shares, the value of which makes it uneconomical to sell, may wish to consider donating them to the charity ShareGift (registered charity no. 1052686). Donated shares are aggregated and sold by ShareGift, the proceeds being passed on to a wide range of charities. Find out more about ShareGift at www.sharegift.org or by telephoning ShareGift on +44 (0)20 7930 3737.

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US Shareholders

(i) ADSs

The Company's American Depositary Shares ('ADS's), each representing three Ordinary shares, are listed on the NASDAQ Global Select Market under the symbol 'SHPGY'. The Company files reports and other documents with the Securities and Exchange Commission ('SEC') that are available for inspection and copying at the SEC's public reference facilities or can be obtained by writing to the Company Secretary.

(ii) ADS Depositary

JPMorgan Chase Bank, N.A. is the depositary for Shire ADSs. All enquiries concerning ADS records, certificates or transfer of Ordinary Shares into ADSs should be addressed to:

JPMorgan Chase & Co.
P.O. Box 64504
St Paul
MN 55164-0504
USA

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General enquiries:

Toll free in US:
Tel +1 800 990 1135

From outside the US:
Tel +1 651 453 2128
Email jpmorgan.adr@wellsfargo.com

Registered Office

22 Grenville Street
St Helier
Jersey JE4 8PX

Registered in Jersey

No. 99854

Corporate Headquarters<

5 Riverwalk
Citywest Business Campus
Dublin 24
Ireland

UK

Hampshire International Business Park
Chineham
Basingstoke
Hampshire RG24 8EP
United Kingdom

Website

www.shire.com

Investor relations
ROW: Clea Rosenfeld

Tel +44 (0)1256 894160
Email investorrelations@shire.com

North America: Eric Rojas

Tel +1 617 551 9715
Email erojas@shire.com

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Registrars

All administrative enquiries relating to shareholders should be addressed to Equiniti, clearly stating the registered shareholder's name and address.

Equiniti

Shire Shareholder Services
Equiniti (Jersey) Limited
PO Box 63
11–12 Esplanade
St Helier
Jersey JE4 8PH

Shareholder helpline

From overseas:
Tel +44 (0)121 415 7047
In the UK:
Tel 0871 384 2553*
*Calls to this number are charged at 8p per minute from a BT landline. Other telephone providers' charges may vary.

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